Title of Document : GENETIC STUDIES OF STUTTERING IN A LARGE WEST AFRICAN FAMILY
نویسندگان
چکیده
Title of Document: GENETIC STUDIES OF STUTTERING IN A LARGE WEST AFRICAN FAMILY Bailey Levis, MS, 2006 Directed By: Associate Professor, Sarah Tishkoff, Department of Biology A large family of West African origin displaying persistent developmental stuttering was ascertained. This family contains 106 individuals, 45 of whom display the phenotype. A genome wide scan was conducted using 366 microsatellite markers, with additional markers in regions of interest. Parametric linkage analyses were conducted under several different models of inheritance patterns. The highest two point LOD scores were obtained under a fully penetrant model on chromosome 1p31 at marker D1S1588 (LOD = 2.97, θ = 0.062), and chromosome 20 at marker D20S873 (LOD = 2.97, θ = 0.15). Multipoint LOD scores provided significant evidence for linkage on chromosome 1 (LOD=4.39) with markers D1S2774 and D1S3471 (114 cM and 117 cM) respectively and suggestive evidence of linkage on chromosome 20 (LOD=2.22) with markers D20S482 and D20S851 (12 cM and 25 cM, respectively). These data provide suggestive evidence for an association of PDS to multiple chromosomal locations. GENETIC STUDIES OF STUTTERING IN A LARGE WEST AFRICAN FAMILY
منابع مشابه
A review on West African Ebola epidemic dynamics models
Background and aims: The world is threatened by disease outbreak that reaches a public health emergency of international concern, studies to inform public and agencies for effective containment strategy are necessary. Several studies provided vital information of the dynamics and control of Ebola epidemic outbreak in West Africa. Methodologies and techniques in those researches...
متن کاملGenetic factors in stuttering confirmed.
To the Editor:-Pedigree or family studies of stuttering have shown increased risks among relatives, but they have not distinguished between the importance of genetic and shared environmental influences. Twin studies that are free of ascertainment bias can distinguish between these causes, but previous twin studies on clinical samples have properly not sought to distinguish. We report data from ...
متن کاملGenetic Analysis of Nigerian Indigenous Goat Populations Using Microsattelite Markers
This study was conducted to determine the genetic relationships among and population history of four Nigerian indigenous goat populations. A total of 200 goats from three breeds namely Sahel (60), Red Sokoto (60), West-African dwarf (60) and Kano Brown, a strain (20), were used for the study. Tissue samples were collected from the ear of animals using an Allflex® ear punch tissue sample collect...
متن کاملAn Analytical Approach to Female Genital Mutilation in West Africa
Female genital mutilation in different parts of the African continent isconsidered as one of the vast territory’s social problems. This social problem whichis accounted as an old tradition in different countries of the African continent hashad so many unpleasant physical and mental effects on urban and rural Africanwomen during recent centuries. Throughout recent decades, considerable effortsha...
متن کاملارزیابی تنوع ژنتیکی و روابط فیلوژنتیکی مرغان بومی ایران بر مبنای توالی ناحیه D- loop از DNA میتوکندریایی
In the present study for evaluation of genetic variability within and between Iranian native fowls, thirty nine blood samples were randomly collected from native fowls breeding stations of west Azarbayjan, Khorasan, Fars, Mazandaran, Yazd and Esfahan provinces. Inorder to compare the obtained results with other Asian, African and European breeds the D-loop sequences of mtDNA taken from GenBan...
متن کامل